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p63 transcriptionally regulates BNC1, a Pol I and Pol II transcription factor that regulates ribosomal biogenesis and epithelial differentiation
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology. (Karin Nylander)
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
2012 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 48, no 9, 1401-1406 p.Article in journal (Refereed) Published
Abstract [en]

The p53-family member, p63 is a transcription factor that influences cellular adhesion, motility, proliferation, survival and apoptosis, and has a major role in regulating epithelial stem cells. Expression of p63 is often dysregulated in squamous cell carcinomas of the head and neck. In this study we show that p63 induces the expression of the basal epithelial transcription factor, Basonuclin 1. Basonuclin 1 is an unusual transcription factor that interacts with a subset of promoters of genes that are transcribed by both RNA polymerase-I and -II and has roles in maintaining ribosomal biogenesis and the proliferative potential of immature epithelial cells. Chromatin immunoprecipitation and reporter assays demonstrate that Basonuclin 1 is a direct transcriptional target of p63 and we also show that up-regulation of Basonuclin 1 is a common event in squamous cell carcinomas of the head and neck. These data identify a new transcriptional programme mediated by p63 regulation of the Basonuclin 1 transcription factor in squamous cell carcinomas and provide a novel link of p63 with the regulation of ribosomal biogenesis in epithelial cancer.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 48, no 9, 1401-1406 p.
Keyword [en]
p63, BNC1, Epithelium, Differentiation, Ribosome synthesis, RNA polymerase I, Squamous cell carcinoma
National Category
Cell and Molecular Biology Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:umu:diva-45966DOI: 10.1016/j.ejca.2011.06.032ISI: 000304243300019PubMedID: 21741828OAI: oai:DiVA.org:umu-45966DiVA: diva2:436611
Available from: 2011-08-24 Created: 2011-08-24 Last updated: 2017-12-08Bibliographically approved

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Boldrup, LindaLaurell, GöranNylander, Karin

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