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Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA. (Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA)
Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA. (Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA)
Department of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA.
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2011 (English)In: Nature, ISSN 0028-0836, Nature, ISSN 1476-4687 EISSN, Vol. 471, no 7339, 480-485 p.Article in journal (Refereed) Published
Abstract [en]

Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.

Place, publisher, year, edition, pages
2011. Vol. 471, no 7339, 480-485 p.
URN: urn:nbn:se:umu:diva-46219DOI: 10.1038/nature09725PubMedID: 21179089OAI: diva2:437450
Available from: 2011-08-29 Created: 2011-08-29 Last updated: 2011-09-29Bibliographically approved

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Schwartz, Yuri B
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