Change search
ReferencesLink to record
Permanent link

Direct link
Identification of functional elements and regulatory circuits by Drosophila modENCODE.
Show others and affiliations
2010 (English)In: Science (New York, N.Y.), ISSN 1095-9203, Vol. 330, no 6012, 1787-1797 p.Article in journal (Refereed) Published
Abstract [en]

To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. We have generated more than 700 data sets and discovered protein-coding, noncoding, RNA regulatory, replication, and chromatin elements, more than tripling the annotated portion of the Drosophila genome. Correlated activity patterns of these elements reveal a functional regulatory network, which predicts putative new functions for genes, reveals stage- and tissue-specific regulators, and enables gene-expression prediction. Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation.

Place, publisher, year, edition, pages
2010. Vol. 330, no 6012, 1787-1797 p.
URN: urn:nbn:se:umu:diva-46221DOI: 10.1126/science.1198374PubMedID: 21177974OAI: diva2:437453
Available from: 2011-08-29 Created: 2011-08-29 Last updated: 2011-11-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Schwartz, Yuri B

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 69 hits
ReferencesLink to record
Permanent link

Direct link