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Polycomb complexes and epigenetic states
Department of Molecular Biology and Biochemistry, Rutgers University, New Jersey, U.S.A..
2008 (English)In: Current Opinion in Cell Biology, ISSN 0955-0674, E-ISSN 1879-0410, Vol. 20, no 3, 266-273 p.Article in journal (Refereed) Published
Abstract [en]

Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown that PcG mechanisms control a large number of genes regulating many cellular functions and all developmental pathways. Current evidence shows that, contrary to the classical picture of their role, PcG complexes do not set a repressed chromatin state that is maintained throughout development but have a much more dynamic role. PcG target genes can become repressed or be reactivated or exist in intermediate states. What controls the balance between repression and derepression is a crucial question in understanding development and differentiation in higher organisms.

Place, publisher, year, edition, pages
2008. Vol. 20, no 3, 266-273 p.
Identifiers
URN: urn:nbn:se:umu:diva-46232DOI: 10.1016/j.ceb.2008.03.002PubMedID: 18439810OAI: oai:DiVA.org:umu-46232DiVA: diva2:437471
Available from: 2011-08-29 Created: 2011-08-29 Last updated: 2017-12-08Bibliographically approved

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