[Polycomb and trithorax control genome expression by determining the alternative epigenetic states of chromatin for key developmental regulators].
2010 (Russian)In: Journal Genetika, ISSN 0016-6758, Vol. 46, no 10, 1413-1416 p.Article in journal (Refereed) Published
The Polycomb (PcG) and Trithorax (TrxG) group proteins are essential for development in all multicellular organisms. Mutations of the PcG and TrxG genes act as early embryonic lethals, while their overexpression correlates with malignancies. Comparative genome analysis showed that PcG and TrxG form a binary regulatory system that functions as an epigenetic rheostat to determine the threshold levels of extracellular signals affecting the expression levels of key developmental genes.
Place, publisher, year, edition, pages
2010. Vol. 46, no 10, 1413-1416 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:umu:diva-46246PubMedID: 21254568OAI: oai:DiVA.org:umu-46246DiVA: diva2:437499
Article in Russian.2011-08-292011-08-292011-09-21Bibliographically approved