Change search
ReferencesLink to record
Permanent link

Direct link
[Polycomb and trithorax control genome expression by determining the alternative epigenetic states of chromatin for key developmental regulators].
Rutgers University, New Jersey, U.S.A..
Rutgers University, New Jersey, U.S.A..
2010 (Russian)In: Journal Genetika, ISSN 0016-6758, Vol. 46, no 10, 1413-1416 p.Article in journal (Refereed) Published
Abstract [en]

The Polycomb (PcG) and Trithorax (TrxG) group proteins are essential for development in all multicellular organisms. Mutations of the PcG and TrxG genes act as early embryonic lethals, while their overexpression correlates with malignancies. Comparative genome analysis showed that PcG and TrxG form a binary regulatory system that functions as an epigenetic rheostat to determine the threshold levels of extracellular signals affecting the expression levels of key developmental genes.

Place, publisher, year, edition, pages
2010. Vol. 46, no 10, 1413-1416 p.
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:umu:diva-46246PubMedID: 21254568OAI: diva2:437499
Article in Russian.Available from: 2011-08-29 Created: 2011-08-29 Last updated: 2011-09-21Bibliographically approved

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Shwartz, Yuri BKahn, Tatiana G
In the same journal
Journal Genetika
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 29 hits
ReferencesLink to record
Permanent link

Direct link