Change search
ReferencesLink to record
Permanent link

Direct link
hobo Induced rearrangements in the yellow locus influence the insulation effect of the gypsy su(Hw)-binding region in Drosophila melanogaster
Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Show others and affiliations
1998 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 149, no 3, 1393-1405 p.Article in journal (Refereed) Published
Abstract [en]

The su(Hw) protein is responsible for the insulation mediated by the su(Hw)-binding region present in the gypsy retrotransposon. In the y2 mutant, su(Hw) protein partially inhibits yellow transcription by repressing the function of transcriptional enhancers located distally from the yellow promoter with respect to gypsy. y2 mutation derivatives have been induced by the insertion of two hobo copies on the both sides of gypsy: into the yellow intron and into the 5' regulatory region upstream of the wing and body enhancers. The hobo elements have the same structure and orientation, opposite to the direction of yellow transcription. In the sequence context, where two copies of hobo are separated by the su(Hw)-binding region, hobo-dependent rearrangements are frequently associated with duplications of the region between the hobo elements. Duplication of the su(Hw)-binding region strongly inhibits the insulation of the yellow promoter separated from the body and wing enhancers by gypsy. These results provide a better insight into mechanisms by which the su(Hw)-binding region affects the enhancer function.

Place, publisher, year, edition, pages
Genetics Society of America , 1998. Vol. 149, no 3, 1393-1405 p.
Keyword [en]
Su(Hw) insulator, hobo element, transcriptional enhancer
National Category
Cell and Molecular Biology
Research subject
Molecular Biology
URN: urn:nbn:se:umu:diva-46266OAI: diva2:437544
Available from: 2011-08-31 Created: 2011-08-29 Last updated: 2011-08-31Bibliographically approved

Open Access in DiVA

No full text

Other links

Free full text

Search in DiVA

By author/editor
Kan, Tatiana
In the same journal
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 30 hits
ReferencesLink to record
Permanent link

Direct link