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SIGN-R1+MHC II+ cells of the splenic marginal zone: a novel type of resident dendritic cells
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
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2011 (English)In: Journal of Leukocyte Biology, ISSN 0741-5400, E-ISSN 1938-3673, Vol. 89, no 4, 607-615 p.Article in journal (Refereed) Published
Abstract [en]

In the spleen, the MZ forms an interface between red and white pulp. Its major function is to trap blood-borne antigens and to reorient them to APCs and lymphocytes. SIGN-R1(+) cells are of the MZ inherent cell population, which for a long time, have been considered as macrophages. We now show that one subpopulation of SIGN-R1(+) cells that express MHC II molecules should be considered as a resident DC. Histological analysis indicated that SIGN-R1(+) cells have dendritic-like protrusions extending into T and B cell areas. Flow cytometry analysis revealed an expression profile of adhesion, costimulatory, and MHC molecules similar to cDCs but distinct from macrophages. Most importantly, SIGN-R1(+)MHC(+) cells were able to present antigen to naïve CD4 T cells, as well as to cross-present soluble, particulate antigens secreted by Listeria monocytogenes to CD8 T cells in vitro and in vivo. Our experiments identified SIGN-R1(+)MHC II(+) cells as professional APCs and indicate their nature as splenic resident DCs.

Place, publisher, year, edition, pages
2011. Vol. 89, no 4, 607-615 p.
Keyword [en]
macrophages, antigen presentation, T cell activation
Identifiers
URN: urn:nbn:se:umu:diva-46328DOI: 10.1189/jlb.0610368PubMedID: 21208895OAI: oai:DiVA.org:umu-46328DiVA: diva2:437886
Available from: 2011-08-30 Created: 2011-08-30 Last updated: 2017-12-08Bibliographically approved

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Gekara, Nelson O

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Molecular Infection Medicine Sweden (MIMS)Department of Clinical Microbiology
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