Lipid rafts clustering and signalling by listeriolysin O.
2004 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 32, no Pt 5, 712-714 p.Article in journal (Refereed) Published
Listeriolysin O, the major virulent determinant of Listeria monocytogenes, is known for forming pores on cholesterol-rich membranes. In the present study, we reveal its other facet, rafts clustering. By immunofluorescence microscopy, we show that the glycosylphosphatidylinositol-anchored proteins CD14 and CD24, which normally exhibit uniform distribution on J774 cells, undergo clustering upon treatment with LLO. The non-raft marker transferrin receptor is unaffected by such treatment. Rafts clustering might explain the induction of tyrosine phosphorylation observed on LLO-treated cells.
Place, publisher, year, edition, pages
2004. Vol. 32, no Pt 5, 712-714 p.
IdentifiersURN: urn:nbn:se:umu:diva-46344DOI: 10.1042/BST0320712PubMedID: 15493995OAI: oai:DiVA.org:umu-46344DiVA: diva2:437899