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Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2010 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 11, no 11, 890-895 p.Article in journal (Refereed) Published
Abstract [en]

Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two-cell-stage arrest of embryos lacking maternal 3-phosphoinositide-dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fertility of double-mutant females. Our study identifies maternal phosphatidylinositol 3-kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice.

Place, publisher, year, edition, pages
2010. Vol. 11, no 11, 890-895 p.
Research subject
Pathology
Identifiers
URN: urn:nbn:se:umu:diva-46368DOI: 10.1038/embor.2010.144ISI: 000283507900016PubMedID: 20930845OAI: oai:DiVA.org:umu-46368DiVA: diva2:437962
Available from: 2011-08-31 Created: 2011-08-31 Last updated: 2017-12-08Bibliographically approved

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