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Effects of working-memory training on striatal dopamine release
Aging Research Center, Karolinska Institute, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Department of Psychology and Logopedics, Åbo Akademi University, Turku, Finland.
Turku PET Center, University of Turku, Turku, Finland.
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2011 (English)In: Science, ISSN 0036-8075, Vol. 333, no 6043, 718- p.Article in journal (Refereed) Published
Abstract [en]

Updating of working memory has been associated with striato-frontal brain regions and phasic dopaminergic neurotransmission. We assessed raclopride binding to striatal dopamine (DA) D2 receptors during a letter-updating task and a control condition before and after 5 weeks of updating training. Results showed that updating affected DA activity before training and that training further increased striatal DA release during updating. These findings highlight the pivotal role of transient neural processes associated with D2 receptor activity in working memory.

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2011. Vol. 333, no 6043, 718- p.
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URN: urn:nbn:se:umu:diva-46467DOI: 10.1126/science.1204978PubMedID: 21817043OAI: diva2:438441
Available from: 2011-09-02 Created: 2011-09-02 Last updated: 2011-09-20Bibliographically approved

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Nyberg, LarsAndersson, MicaelDahlin, ErikaNeely, Anna S
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