Change search
ReferencesLink to record
Permanent link

Direct link
Heritability of the cortisol regulation in children
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
Show others and affiliations
2011 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, Vol. 14, no 6, 553-561 p.Article in journal (Refereed) Published
Abstract [en]

Background: The normal development of cortisol regulation during childhood is thought to be influenced by a complex interplay between environmental and genetic factors. Method: The aim of this study was to estimate genetic and environmental influences on basal cortisol levels in a sample of 151 twin pairs aged 9-16 years. Salivary cortisol was collected on two consecutive days when the children attended school immediately after awakening, 30 min post-awakening and at bedtime. Results: Heritability was highest (60%) for cortisol levels about 30 min after awakening. For samples taken immediately at awakening heritability was less pronounced (28%) and in the evening low (8%). Conclusion: The limited genetic influence on evening levels, moderate on cortisol at awakening and high on awakening response, might imply two genetic regulation patterns, one specifically for awakening response and one for the circadian rhythm proper. These findings could explain divergent results in previous studies and highlight the importance of taking the circadian rhythm into account in studies of cortisol levels in children.

Place, publisher, year, edition, pages
2011. Vol. 14, no 6, 553-561 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-46703DOI: 10.1375/twin.14.6.553ISI: 000298625100007OAI: diva2:439916
Available from: 2011-09-09 Created: 2011-09-09 Last updated: 2012-01-31Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Gustafsson, Per E
By organisation
Family Medicine
In the same journal
Twin Research and Human Genetics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 52 hits
ReferencesLink to record
Permanent link

Direct link