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Hemodynamic responses after tilt reversal in FAP
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Clinical Physiology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
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2011 (English)In: Amyloid: Journal of Protein Folding Disorders, ISSN 1350-6129, E-ISSN 1744-2818, Vol. 18, no Suppl 1, 161-163 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to evaluate hemodynamic responses after tilt reversal in familial amyloid polyneuropathy (FAP). Systolic blood pressure (BP) and heart rate variability (HRV) were analyzed in the baseline, 70-degree upright position, and after tilt reversal in 10 patients with FAP and 14 healthy controls. Maximum systolic BP after tilt reversal was increased in FAP as compared to baseline (BP overshoot), whereas controls showed a significantly lower BP overshoot. In all states, all HRV parameters were significantly lower than those of the controls. In a linear regression analysis adjusted for age, we found a significant inverse relation between BP overshoot and HRV in all three states. Five patients presented atrial arrhythmia precluding HRV analysis: four of those presented BP overshoots 12 mmHg. BP overshoot may be a useful marker to assess the progression of cardiac autonomic dysfunction, especially since heart arrhythmia in many patients with FAP prevents HRV analysis.

Place, publisher, year, edition, pages
2011. Vol. 18, no Suppl 1, 161-163 p.
Identifiers
URN: urn:nbn:se:umu:diva-46801DOI: 10.3109/13506129.2011.574354062PubMedID: 21838474OAI: oai:DiVA.org:umu-46801DiVA: diva2:441108
Available from: 2011-09-14 Created: 2011-09-14 Last updated: 2017-12-08Bibliographically approved

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Obayashi, KHörnsten, RolfWiklund, UrbanKarlsson, MarcusOkamoto, SSuhr, Ole B
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