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The response to mechanical distension of the non-pregnant human uterus in vivo
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynaecology.
1978 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The ability of the uterus to contract in response to mechanical distension has been utilized in the development of a method, hysterometry, for the quantification of hormonal and pharmacological effects on the human myometrium in vivo. The method has been built up with due consideration for laws from mechanics of materials and hydrodynamics. By applying mathematical theorems and accepting certain approximations, the basic results of recordings of intrauterine pressure are transformed inte wall tension, allowing for the size of the uterus. The equivalent of an elasticity modulus in the myometrium has been used as a synthetic discriminator (without any real physiologic correlation) for the evaluation of hormonal and pharmacological effects.

Hysterometry har been used for the evaluation of uterine tonicity during the menstrual cycle. It was demonstrated that uterine tonicity is higher in the proliferative than in the secretory phase. The uterine tonicity correlated well with the concentrations in serum of estradiol and progesterone at the time of the examination.

Hysterometry has also been used for the evaluation of effects of inhibitors of prostaglandin synthesis (Naproxen Sodium and Naproxen acid) and of a selective beta-2-receptor stimulator (Salbutamol) upon the uterus in women with primary dysmenorrhea. It was shown that uterine tonicity was high on the first day of menstruation in untreated or placebo-treated dysmenorrheic women. Administration of inhibitors of prostaglandin synthesis or beta-2-receptor stimulating agents markedly decreased the uterine tonicity and relieved the menstrual pain.

Place, publisher, year, edition, pages
Umeå: Umeå universitet , 1978. , 31 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 37
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:umu:diva-46962OAI: oai:DiVA.org:umu-46962DiVA: diva2:441607
Public defence
1978-06-08, Humanisthuset, hörsal G, Umeå universitet, Umeå, 09:15 (English)
Projects
digitalisering@umu
Note

 

Available from: 2011-09-16 Created: 2011-09-16 Last updated: 2016-02-17Bibliographically approved
List of papers
1. Determination of tonicity in the non-pregnant human uterus in vivo
Open this publication in new window or tab >>Determination of tonicity in the non-pregnant human uterus in vivo
1979 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 58, no 6, 555-559 p.Article in journal (Refereed) Published
Abstract [en]

The method hysterometry has been designed for the study of the effect upon the uterine muscle of pharmacologically active agents. Hysterometry has earlier been used on the pregnant uterus and is now described for the non-pregnant situation. The capacity of the technique is exemplified with results achieved in a study of the effect of prostaglandin synthetase inhibitors and β-receptor stimulating agents during dysmenorrhea.

Read More: http://informahealthcare.com/doi/abs/10.3109/00016347909154618

National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:umu:diva-46956 (URN)
Available from: 2011-09-16 Created: 2011-09-16 Last updated: 2017-12-08Bibliographically approved
2. Uterine tonicity in proliferative and secretory phases of the menstrual cycle
Open this publication in new window or tab >>Uterine tonicity in proliferative and secretory phases of the menstrual cycle
1981 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 60, no 5, 441-445 p.Article in journal (Refereed) Published
Abstract [en]

Hysterometry, a method for the quantitative evaluation of drug effect on the myometrium, has now been applied in a study of the changes in uterine tonicity during the menstrual cycle. Six nulli-gravidae women with regular menstrual periods and normal gynecological examination findings, were studied. Hysterometry was performed in the midproliferative, ovulatory, and midsecretory periods of the cycle and on the first day of menstruation. Uterine tonicity was found to be higher during the proliferative compared with the secretory phase. The change in uterine tonicity was correlated with a change in the quotient of concentration of estradiol and progesterone in serum (E2/P).

Read More: http://informahealthcare.com/doi/abs/10.3109/00016348109155458

National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:umu:diva-46958 (URN)
Available from: 2011-09-16 Created: 2011-09-16 Last updated: 2017-12-08Bibliographically approved
3. A hysterometric study of the effect of inhibitors of prosta-glandin synthesis in primary dysmenorrhea
Open this publication in new window or tab >>A hysterometric study of the effect of inhibitors of prosta-glandin synthesis in primary dysmenorrhea
(English)Manuscript (preprint) (Other academic)
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:umu:diva-46960 (URN)
Available from: 2011-09-16 Created: 2011-09-16 Last updated: 2011-09-16Bibliographically approved
4. The effect of salbutamol on the non-pregnant human uterus in vivo: a hysterometric study in dysmenorrheic women
Open this publication in new window or tab >>The effect of salbutamol on the non-pregnant human uterus in vivo: a hysterometric study in dysmenorrheic women
1981 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 60, no 4, 349-352 p.Article in journal (Refereed) Published
Abstract [en]

Uterine tonicity has been determined by means of hysterometry on the first day of menstruation in 5 women with severe primary dysmenorrhea. The effect of intravenous infusion of salbutamol in a dose of 10 μg/min was evaluated. The results indicate that this β2-receptor stimulating agent is capable of eliciting a marked decrease in uterine tonicity in dysmenorrheic women. The diminished uterine tonicity was closely associated with pain relief.

Read More: http://informahealthcare.com/doi/abs/10.3109/00016348109154122

National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:umu:diva-46961 (URN)
Available from: 2011-09-16 Created: 2011-09-16 Last updated: 2017-12-08Bibliographically approved

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