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Analysis of DNA repair gene polymorphisms and survival in low-grade and anaplastic gliomas
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
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2011 (English)In: Journal of Neuro-Oncology, ISSN 0167-594X, E-ISSN 1573-7373, Vol. 105, no 3, p. 531-538Article in journal (Refereed) Published
Abstract [en]

The purpose of this study was to explore the variation in DNA repair genes in adults with WHO grade II and III gliomas and their relationship to patient survival. We analysed a total of 1,458 tagging single-nucleotide polymorphisms (SNPs) that were selected to cover DNA repair genes, in 81 grade II and grade III gliomas samples, collected in Sweden and Denmark. The statistically significant genetic variants from the first dataset (P < 0.05) were taken forward for confirmation in a second dataset of 72 grade II and III gliomas from northern UK. In this dataset, eight gene variants mapping to five different DNA repair genes (ATM, NEIL1, NEIL2, ERCC6 and RPA4) which were associated with survival. Finally, these eight genetic variants were adjusted for treatment, malignancy grade, patient age and gender, leaving one variant, rs4253079, mapped to ERCC6, with a significant association to survival (OR 0.184, 95% CI 0.054-0.63, P = 0.007). We suggest a possible novel association between rs4253079 and survival in this group of patients with low-grade and anaplastic gliomas that needs confirmation in larger datasets.

Place, publisher, year, edition, pages
2011. Vol. 105, no 3, p. 531-538
Keywords [en]
Gliomas WHO grade II/III, DNA repair, ERCC6, Outcome, Polymorphism
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-47496DOI: 10.1007/s11060-011-0614-5PubMedID: 21643987OAI: oai:DiVA.org:umu-47496DiVA, id: diva2:442677
Available from: 2011-09-22 Created: 2011-09-22 Last updated: 2018-06-08Bibliographically approved

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Wibom, CarlSjöström, SaraHenriksson, RogerBrännström, ThomasAndersson, UlrikaMelin, Beatrice S

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