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Common variation at 10p12.31 near MLLT10 influences meningioma risk
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
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2011 (English)In: Nature Genetics, ISSN 1061-4036, Vol. 43, no 9, 825-827 p.Article in journal (Refereed) Published
Abstract [en]

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

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London: Nature America, Inc. , 2011. Vol. 43, no 9, 825-827 p.
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URN: urn:nbn:se:umu:diva-47382DOI: 10.1038/ng.879OAI: diva2:443704
Available from: 2011-09-26 Created: 2011-09-20 Last updated: 2011-09-28Bibliographically approved

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Melin, BeatriceAndersson, UlrikaBrännström, ThomasHenriksson, Roger
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OncologyDepartment of Medical Biosciences
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