Change search
ReferencesLink to record
Permanent link

Direct link
Neural correlates of emotional processing in idiopathic environmental intolerance: an fmri study
Umeå University, Faculty of Social Sciences, Department of Psychology.
2011 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Idiopathic environmental intolerance (IEI) is still medically unexplained. Conditioning and

sensitization have been proposed to contribute to the symptoms. No study to date has used

functional magnetic resonance imaging (fMRI) to study brain activation in IEI. The objective of the present study was to investigate whether individuals with IEI during chemosensory exposure activate brain circuitries associated with negative emotional processing and to examine if they sensitize to chemosensory stimuli. Brain activation was studied with fMRI in 26 female subjects with IEI and 30 age- and gender-matched healthy controls during exposure to olfactory and chemosomatosensory stimuli. Stimuli were presented in a blocked design with intensity ratings during each block. Subjects with IEI showed increased activation in amygdala, insula, dorsal anterior cingulate cortex and dorsal prefrontal cortex during exposure to carbon dioxide. In addition, they showed decreased activation in medial refrontal cortex. These results imply negative emotional processing in IEI that is similar to what is seen in anxiety disorders. Further, specific phobia is proposed as a model for the understanding of how IEI develops and is maintained. The findings might have implications for the treatment of IEI.

Place, publisher, year, edition, pages
2011. , 19 p.
National Category
URN: urn:nbn:se:umu:diva-47687Archive number: P770OAI: diva2:443859
Subject / course
Examensarbete i psykologi
Educational program
Programme for Master of Science in Psychology
Available from: 2011-11-22 Created: 2011-09-27 Last updated: 2011-11-22Bibliographically approved

Open Access in DiVA

P770.pdf(739 kB)308 downloads
File information
File name FULLTEXT01.pdfFile size 739 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Rosén, Ann
By organisation
Department of Psychology

Search outside of DiVA

GoogleGoogle Scholar
Total: 308 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 111 hits
ReferencesLink to record
Permanent link

Direct link