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Impact of therapy on quality of life, neurocognitive function and their correlates in glioblastoma multiforme: a review
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Radiumhemmet, Karolinska Hospital, Stockholm, Sweden; Department of Oncology, Finsencenter, University Hospital, 9 Blegdamsvej, 2100 Copenhagen, Denmark.
2011 (English)In: Journal of Neuro-Oncology, ISSN 0167-594X, E-ISSN 1573-7373, Vol. 104, no 3, 639-646 p.Article, review/survey (Refereed) Published
Abstract [en]

The maintenance of quality of life (QoL) in patients with high-grade glioma is an important endpoint during treatment, particularly in those with glioblastoma multiforme (GBM) given its dismal prognosis despite limited advances in standard therapy. It has proven difficult to identify new therapies that extend survival in patients with recurrent GBM, so one of the primary aims of new therapies is to reduce morbidity, restore or preserve neurologic functions, and the capacity to perform daily activities. Apart from temozolomide, cytotoxic chemotherapeutic agents do not appear to significantly impact response or survival, but produce toxicity that is likely to negatively impact QoL. New biological agents, such as bevacizumab, can induce a clinically meaningful proportion of durable responses among patients with recurrent GBM with an acceptable safety profile. Emerging evidence suggests that bevacizumab produces an improvement or preservation of neurocognitive function in GBM patients, suggestive of QoL improvement, in most poor-prognosis patients who would otherwise be expected to show a sudden and rapid deterioration in QoL.

Place, publisher, year, edition, pages
Boston: Nijhoff , 2011. Vol. 104, no 3, 639-646 p.
Keyword [en]
Quality of life, Glioblastoma multiforme, Bevacizumab
National Category
Neurology Cancer and Oncology
URN: urn:nbn:se:umu:diva-47663DOI: 10.1007/s11060-011-0565-xISI: 000294736700003OAI: diva2:445228
Available from: 2011-10-03 Created: 2011-09-27 Last updated: 2011-10-04Bibliographically approved

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