Change search
ReferencesLink to record
Permanent link

Direct link
Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C > T and 1298A > C genotypes and haplotypes: evidence for an association with hemorrhagic stroke
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Department of Clinical Nutrition, Göteborg University, Gothenburg, Sweden.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.ORCID iD: 0000-0001-9581-3845
Show others and affiliations
2011 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, Vol. 49, no 9, 1555-1562 p.Article in journal (Refereed) Published
Abstract [en]

Background: Abnormalities in homocysteine metabolism have been suggested as risk factors for stroke. The aim of this prospective study was to examine whether total plasma homocysteine concentration (tHcy) and its main genetic determinant, methylene tetrahydrofolate reductase (MTHFR) polymorphisms, were associated with first ischemic or hemorrhagic stroke.

Methods: This was a nested case-referent study of 321 ischemic and 60 hemorrhagic stroke cases, defined by WHO MONICA criteria and each matched with two event-free referents for sex, age, cohort, recruitment date and geographical area. All subjects were from the population-based Northern Sweden Health and Disease Study cohorts. Odds ratios were determined by conditional logistic regression.

Results: The mean follow-up time was 4.2 years. Both tHcy and MTHFR were independent predictors of hemorrhagic stroke in multivariate models including body mass index, hypertension and, for MTHFR, tHcy [OR for the highest vs. lowest tHcy quartile 8.13 (95% CI 1.83-36.1), p(trend)=0.002; OR for MTHFR 677TT vs. 677CC genotype 3.62 (95% CI 0.77-17.0), p(trend)=0.040]. Haplotype analyses confirmed that the MTHFR 677T-1298A haplotype was positively associated with hemorrhagic stroke [OR 1.81 (95% CI 1.09-3.00), p=0.022], whereas the MTHFR 677C-1298C haplotype was not significantly related to either hemorrhagic or ischemic stroke. Neither tHcy nor the MTHFR polymorphisms were significant predictors of ischemic stroke.

Conclusion: Both elevated plasma homocysteine levels and the MTHFR 677T allele are indicators of increased risk of hemorrhagic stroke in the northern Swedish population.

Place, publisher, year, edition, pages
Berlin: Walter de Gruyter , 2011. Vol. 49, no 9, 1555-1562 p.
Keyword [en]
cerebral hemorrhage, homocysteine, MTHFR, risk factors, stroke
National Category
Medical Laboratory and Measurements Technologies
URN: urn:nbn:se:umu:diva-47652DOI: 10.1515/CCLM.2011.234ISI: 000294841100025PubMedID: 21631392OAI: diva2:445290
Available from: 2011-10-03 Created: 2011-09-27 Last updated: 2015-04-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hultdin, JohanVan Guelpen, BethanyHallmans, GöranWeinehall, LarsStegmayr, BirgittaNilsson, Torbjörn K.
By organisation
Clinical chemistryPathologyNutritional ResearchEpidemiology and Global HealthMedicine
In the same journal
Clinical Chemistry and Laboratory Medicine
Medical Laboratory and Measurements Technologies

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 62 hits
ReferencesLink to record
Permanent link

Direct link