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Do both areal BMD and injurious falls explain the higher incidence of fractures in women than in men?
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Idrottsmedicin.
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2011 (Engelska)Ingår i: Calcified Tissue International, ISSN 0171-967X, E-ISSN 1432-0827, Vol. 89, nr 3, s. 203-210Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The higher incidence of fractures in women than in men is generally attributed to the lower areal bone mineral density (areal BMD, g/cm(2)) of the former. The purpose of the present study was to investigate both areal BMD and injurious falls as risk factors for fractures. In a first cohort, areal BMD was measured in 5,131 men and women (age range 40-95 years). In a second cohort, consisting of 26,565 men and women (age range 40-69 years), a health survey was conducted including questions about lifestyle and medication. Main outcome measures included validated prospective injurious falls and fractures in both cohorts. The higher areal BMD and femoral neck BMD in men compared to women (P < 0.001) were explained by a higher diameter of the femoral neck. Importantly, the diameter of the femoral neck was not associated with fractures in either sex (hazard ratio [HR] 0.94-1.04, P > 0.05 for all), suggesting that a higher areal BMD and lower incidence of osteoporosis in men do not explain their lower incidence of fractures. In contrast, women were more prone to sustain injurious falls than men in both cohorts investigated (HR for women = 1.61 and 1.84, P < 0.001 for both), resulting in a higher incidence of fractures (HR for women = 2.24 and 2.36, P < 0.001 for both). The number of injurious falls and fractures occurring each month during the study period showed a very strong correlation in both women (r = 0.95, P < 0.00001) and men (r = 0.97, P < 0.00001). In summary, low areal BMD, and thus osteoporosis, may not explain the higher fracture incidence in women than in men. Instead, a higher incidence of injurious falls in women was strongly associated with the higher fracture risk.

Ort, förlag, år, upplaga, sidor
Springer , 2011. Vol. 89, nr 3, s. 203-210
Nyckelord [en]
Falling, Fracture, Prevention, Bone density, Osteoporosis
Nationell ämneskategori
Geriatrik Idrottsvetenskap
Identifikatorer
URN: urn:nbn:se:umu:diva-47981DOI: 10.1007/s00223-011-9507-zPubMedID: 21667164OAI: oai:DiVA.org:umu-47981DiVA, id: diva2:445937
Tillgänglig från: 2011-10-05 Skapad: 2011-10-05 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Nordström, PeterEklund, FredrikBjörnstig, UlfNordström, AnnaLorentzon, RonnyGustafson, Yngve

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Nordström, PeterEklund, FredrikBjörnstig, UlfNordström, AnnaLorentzon, RonnyGustafson, Yngve
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