Association of adipose tissue blood flow with fat depot sizes and adipokines in women
2012 (English)In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 36, no 6, 783-789 p.Article in journal (Refereed) Published
Objective: To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.
Subjects: In all, 43 healthy women were divided into four groups: normal-weight (n=11) and obese (n=11) pre-menopausal women and normal-weight (n=10) and obese (n=11) post-menopausal women.
Methods: Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids.
Results: Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all P<0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P=0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow.
Conclusion: ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow. International Journal of Obesity advance online publication, 26 July 2011; doi:10.1038/ijo.2011.152.
Place, publisher, year, edition, pages
Nature Publishing Group, 2012. Vol. 36, no 6, 783-789 p.
adipose tissue, blood flow, body fat distribution, leptin, women
Other Clinical Medicine
Research subject Medicine
IdentifiersURN: urn:nbn:se:umu:diva-48345DOI: 10.1038/ijo.2011.152ISI: 000305282400004PubMedID: 21792171OAI: oai:DiVA.org:umu-48345DiVA: diva2:448922