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Deep brain stimulation of caudal zona incerta and subthalamic nucleus in patients with Parkinson’s disease: effects on voice intensity
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
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2011 (English)In: Parkinson’s Disease, ISSN 2042-0080, Vol. 2011, 658956- p.Article in journal (Refereed) Published
Abstract [en]

Deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson’s disease (PD) affects speech in small, inconsistent ways. However, voice intensity generally increases. Recently the caudal zona inserta (cZi) has been investigated as an alternate target in DBS treatment of PD. The effects of cZi-DBS on voice intensity have not yet been investigated. The aim of this study was to compare the voice intensity effects of cZi-DBS and STN-DBS in PD patients. Voice intensity during reading and intensity decay during rapid syllable repetition were measured for eight STN-DBS and eight cZi-DBS patients in a pre-surgical baseline and then on- and off-stimulation 12 months after surgery. Voice intensity on-stimulation was larger than off-stimulation for the STN-DBS patients, but smaller for the cZi-DBS patients. There were no significant changes in intensity decay. The results suggest that cZi and STN are involved differently in neuromuscular control of the speech respiratory subsystem.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2011. Vol. 2011, 658956- p.
National Category
Neurology
Research subject
Neurology; Neurosurgery; Linguistics
Identifiers
URN: urn:nbn:se:umu:diva-48425DOI: 10.4061/2011/658956OAI: oai:DiVA.org:umu-48425DiVA: diva2:450268
Projects
Effekter av djup hjärn-stimulering på tal hos Parkinsonpatienter
Funder
Swedish Research Council, 2009-946
Available from: 2012-04-13 Created: 2011-10-20 Last updated: 2012-06-04Bibliographically approved

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Lundgren, SofieSaeys, ThomasKarlsson, FredrikOlofsson, KatarinaBlomstedt, PatricLinder, JanNordh, ErikZafar, HamayunDoorn, Jan van
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Speech and Language TherapyOtorhinolaryngologyClinical NeuroscienceClinical Oral Physiology
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