Change search
ReferencesLink to record
Permanent link

Direct link
KIBRA polymorphism is related to enhanced memory and elevated hippocampal processing
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Stockholm University.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.ORCID iD: 0000-0002-8114-7615
Gothenburg University.
Show others and affiliations
2011 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 31, no 40, 14218-14222 p.Article in journal (Refereed) Published
Abstract [en]

Several studies have linked the KIBRA rs17070145 T polymorphism to superior episodic memory in healthy humans. One study investigated the effect of KIBRA on brain activation patterns (Papassotiropoulos et al., 2006) and observed increased hippocampal activation in noncarriers of the T allele during retrieval. Noncarriers were interpreted to need more hippocampal activation to reach the same performance level as T carriers. Using large behavioral (N = 2230) and fMRI (N = 83) samples, we replicated the KIBRA effect on episodic memory performance, but found increased hippocampal activation in T carriers during episodic retrieval. There was no evidence of compensatory brain activation in noncarriers within the hippocampal region. In the main fMRI sample, T carriers performed better than noncarriers during scanning but, importantly, the difference in hippocampus activation remained after post hoc matching according to performance, sex, and age (N = 64). These findings link enhanced memory performance in KIBRA T allele carriers to elevated hippocampal functioning, rather than to neural compensation in noncarriers.

Place, publisher, year, edition, pages
Bethesda, Md.: The Soc. , 2011. Vol. 31, no 40, 14218-14222 p.
National Category
URN: urn:nbn:se:umu:diva-48524DOI: 10.1523/JNEUROSCI.3292-11.2011PubMedID: 21976506OAI: diva2:450434
Available from: 2011-10-20 Created: 2011-10-20 Last updated: 2015-12-07
In thesis
1. Genes to remember: imaging genetics of hippocampus-based memory functions
Open this publication in new window or tab >>Genes to remember: imaging genetics of hippocampus-based memory functions
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In the field of imaging genetics, brain function and structure are used as intermediate phenotypes between genes and cognition/diseases to validate and extend findings from behavioral genetics. In this thesis, three of the strongest candidate genes for episodic memory, KIBRA, BDNF, and APOE, were examined in relation to memory performance and hippocampal/parahippocampal fMRI blood-oxygen level-dependent (BOLD) signal. A common T allele in the KIBRA gene was previously associated with superior memory, and increased hippocampal activation was observed in noncarriers of the T allele which was interpreted as reflecting compensatory recruitment. The results from the first study revealed that both memory performance and hippocampal activation at retrieval was higher in T allele carriers (study I). The BDNF 66Met and APOE ε4 alleles have previously been associated with poorer memory performance, but their relation to brain activation has been inconsistent with reports of both increased and decreased regional brain activation relative to noncarriers. Here, decreased hippocampal/parahippocampal activation was observed in carriers of BDNF 66Met (study II) as well as APOE ε4 (study III) during memory encoding. In addition, there was an additive gene-gene effect of APOE and BDNF on hippocampal and parahippocampal activation (study III). Collectively, the results from these studies on KIBRA, BDNF, and APOE converge on higher medial temporal lobe activation for carriers of a high-memory associated allele, relative to carriers of a low-memory associated allele. In addition, the observed additive effect of APOE and BDNF demonstrate that a larger amount of variance in BOLD signal change can be explained by considering the combined effect of more than one genetic polymorphism. These imaging genetics findings support and extend previous knowledge from behavioral genetics on the role of these memory-related genes.

Place, publisher, year, edition, pages
Umeå: Umeå Universitet, 2013. 84 p.
Umeå University medical dissertations, ISSN 0346-6612 ; 1580
Imaging genetics, fMRI, Episodic memory, SNP, KIBRA, BDNF, APOE, Hippocampus, Parahippocampus
National Category
urn:nbn:se:umu:diva-71141 (URN)978-91-7459-598-7 (PDF) (ISBN)978-91-7459-597-0 (Print) (ISBN)
Public defence
2013-06-14, BiA 201, Biologihuset, Umeå universitet, Umeå, 10:00 (English)
Available from: 2013-05-24 Created: 2013-05-20 Last updated: 2015-04-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kauppi, KarolinaAdolfsson, RolfNyberg, Lars
By organisation
PhysiologyUmeå Centre for Functional Brain Imaging (UFBI)PsychiatryDiagnostic Radiology
In the same journal
Journal of Neuroscience

Search outside of DiVA

GoogleGoogle ScholarTotal: 1 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 370 hits
ReferencesLink to record
Permanent link

Direct link