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The psychological neuroscience of depression: implications for understanding effects of deep brain stimulation
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
2011 (English)In: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 52, no 5, 411-419 p.Article in journal (Refereed) Published
Abstract [en]

In this article it is suggested that current psychological theories of depression presuppose that this condition will develop as a result of a vicious circle involving negatively biased communication between systems of emotional stress-/alarm-signaling, executive functions and mood regulation. These systems may from a neuroanatomical point of view be located in the limbic system, the orbitofrontal and lateral prefrontal cortex and the hypothalamus-pituitary-adrenal (HPA-) axis respectively. The theoretical and practical implications of this model for the understanding of pharmacological treatments of depression are briefly discussed and this theory is related to the catecholamine hypothesis of depression. The model is furthermore discussed in relation to deep brain stimulation (DBS) of treatment resistant major depression. Similarities and differences between this perspective and the one advocated by the "homeostatic theory" of depression are discussed. It is concluded that a topographical psychological theory may offer a useful heuristic in thinking about depression and that it offers several testable predictions about treatments of the disorder.

Place, publisher, year, edition, pages
Oxford: Blackwell , 2011. Vol. 52, no 5, 411-419 p.
Keyword [en]
Major depressive disorder, depression, psychology, deep brain stimulation, neurosurgery, cognitive theory
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URN: urn:nbn:se:umu:diva-48443DOI: 10.1111/j.1467-9450.2011.00891.xISI: 000295081300001OAI: diva2:451018
Available from: 2011-10-24 Created: 2011-10-20 Last updated: 2012-06-04Bibliographically approved

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