Change search
ReferencesLink to record
Permanent link

Direct link
Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer
Show others and affiliations
2011 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 105, no 9, 1458-1464 p.Article in journal (Refereed) Published
Abstract [en]

Background: It has been suggested that the relative importance of oestrogen-metabolising pathways may affect the risk of oestrogen-dependent tumours including endometrial cancer. One hypothesis is that the 2-hydroxy pathway is protective, whereas the 16α-hydroxy pathway is harmful.

Methods: We conducted a case-control study nested within three prospective cohorts to assess whether the circulating 2-hydroxyestrone : 16α-hydroxyestrone (2-OHE1 : 16α-OHE1) ratio is inversely associated with endometrial cancer risk in postmenopausal women. A total of 179 cases and 336 controls, matching cases on cohort, age and date of blood donation, were included. Levels of 2-OHE1 and 16α-OHE1 were measured using a monoclonal antibody-based enzyme assay.

Results: Endometrial cancer risk increased with increasing levels of both metabolites, with odds ratios in the top tertiles of 2.4 (95% CI=1.3, 4.6; P(trend)=0.007) for 2-OHE1 and 1.9 (95% CI=1.1, 3.5; P(trend)=0.03) for 16α-OHE1 in analyses adjusting for endometrial cancer risk factors. These associations were attenuated and no longer statistically significant after further adjustment for oestrone or oestradiol levels. No significant association was observed for the 2-OHE1 : 16α-OHE1 ratio.

Conclusion: Our results do not support the hypothesis that greater metabolism of oestrogen via the 2-OH pathway, relative to the 16α-OH pathway, protects against endometrial cancer.

Place, publisher, year, edition, pages
London: Harcourt Publishers , 2011. Vol. 105, no 9, 1458-1464 p.
Keyword [en]
endometrial cancer, nested case–control study, oestrogen metabolites, 2-hydroxyestrone, 16α-hydroxyestrone, post-menopause
National Category
Cancer and Oncology
URN: urn:nbn:se:umu:diva-48717DOI: 10.1038/bjc.2011.381PubMedID: 21952628OAI: diva2:451910
Available from: 2011-10-27 Created: 2011-10-27 Last updated: 2011-11-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Idahl, AnnikaOhlson, NinaLenner, PerHallmans, GöranLundin, Eva
By organisation
Obstetrics and GynaecologyPathologyOncologyNutritional Research
In the same journal
British Journal of Cancer
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 51 hits
ReferencesLink to record
Permanent link

Direct link