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Prognostic value of pre-transplant cardiomyopathy in Swedish liver transplanted patients for familial amyloidotic polyneuropathy
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
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2011 (English)In: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, ISSN 1744-2818, Vol. 18 Suppl 1, 166-8 p.Article in journal (Refereed) Published
Abstract [en]

Liver transplantation (LTx) for familial amyloidotic polyneuropathy (FAP) is a recognized treatment for halting disease progression. Since cardiac complications are the main cause of postoperative death in FAP patients, we studied the potential relationship between pre-LTx amyloid heart disease and post-LTx mortality. Seventy-five Swedish patients who underwent LTx (72 Val30Met and 3 non-Val30Met patients) were available for the study. An intra-ventricular septal (IVS) thickness more than 15 mm at the pre-LTx evaluation was defined as cardiomyopathy. Nine patients out of 75 patients died, all were males and all belonged to the late onset group (age at onset ≥50 years). Four had cardiomyopathy at the pre-LTx evaluation. Survival rate was significantly higher in patients without cardiomyopathy at LTx compared to those with cardiomyopathy. Our results suggest that cardiomyopathy at LTx has an impact on the outcome of LTx for FAP.Read More:

Place, publisher, year, edition, pages
Pearl River: Parthenon , 2011. Vol. 18 Suppl 1, 166-8 p.
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Clinical Medicine
URN: urn:nbn:se:umu:diva-49012DOI: 10.3109/13506129.2011.574354064PubMedID: 21838476OAI: diva2:452594
Available from: 2011-10-31 Created: 2011-10-31 Last updated: 2012-10-19Bibliographically approved

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Okamoto, SadahisaWixner, JonasLindqvist, PerHenein, MichaelSuhr, Ole B
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