Selective IgA deficiency in autoimmune diseases
2011 (English)In: Molecular medicine, ISSN 1528-3658, Vol. 17, no 11-12, 1383- p.Article, review/survey (Refereed) Published
Selective IgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves' disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), celiac disease (CD), myasthenia gravis (MG) and rheumatoid arthritis (RA) based both on our own, recent, large scale screening results and literature data. Genetic factors are important for the development of both IgAD and various autoimmune disorders, including GD, SLE, T1D, CD, MG and RA, and a strong association with the MHC region has been reported. In addition, non-MHC genes, such as IFIH1 and CLEC16A, are also associated with the development of IgAD and some of the above diseases. This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders.
Place, publisher, year, edition, pages
Baltimore, Md.: Johns Hopkins University Press, 2011. Vol. 17, no 11-12, 1383- p.
systemic lupus erythematosus, type I interferon system, candidate gene study, single nucleotide polymorphism, IKBKE, IL8
Rheumatology and Autoimmunity
IdentifiersURN: urn:nbn:se:umu:diva-49015DOI: 10.2119/molmed.2011.00195PubMedID: 21826374OAI: oai:DiVA.org:umu-49015DiVA: diva2:452609