Preferential association of interferon regulatory factor 5 gene variants with seronegative rheumatoid arthritis in 2 Swedish case-control studies
2011 (English)In: Journal of Rheumatology, ISSN 0315-162X, E-ISSN 1499-2752, Vol. 38, no 10, 2130-2132 p.Article in journal (Refereed) Published
Objective: Two interferon regulatory factor 5 (IRF5) gene variants were examined for association with rheumatoid arthritis (RA).
Methods: A total of 2300 patients with RA and 1836 controls were recruited from 2 independent RA studies in Sweden. One insertion-deletion polymorphism (CGGGG indel) and one single-nucleotide polymorphism (rs10488631) in the IRF5gene were genotyped and analyzed within RA subgroups stratified by rheumatoid factor (RF) and anticitrullinated peptide antibodies (ACPA).
Results: The CGGGG indel was preferentially associated with the RF-negative (OR 1.29, p = 7.9 × 10−5) and ACPA-negative (OR 1.27, p = 7.3 × 10−5) RA subgroups compared to the seropositive counterparts. rs10488631 was exclusively associated within the seronegative RA subgroups (RF-negative: OR 1.24, p = 0.016; ACPA-negative: OR 1.27, p = 4.1 × 10−3).
Conclusion: Both the CGGGG indel and rs10488631 are relevant for RA susceptibility, especially for seronegative RA.
Place, publisher, year, edition, pages
Toronto: Journal of Rheumatology Pub. Co. , 2011. Vol. 38, no 10, 2130-2132 p.
Rheumatology and Autoimmunity
IdentifiersURN: urn:nbn:se:umu:diva-49016DOI: 10.3899/jrheum.110322PubMedID: 21807777OAI: oai:DiVA.org:umu-49016DiVA: diva2:452616