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Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Pulmonary Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Pulmonary Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Pulmonary Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Pulmonary Medicine.
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2011 (English)In: Respiratory research (Online), ISSN 1465-9921, E-ISSN 1465-993X, Vol. 12, no 74, 8- p.Article in journal (Refereed) Published
Abstract [en]

Background: Regulatory T cells have been implicated in the pathogenesis of COPD by the increased expression of CD25 on helper T cells along with enhanced intracellular expression of FoxP3 and low/absent CD127 expression on the cell surface.

Method: Regulatory T cells were investigated in BALF from nine COPD subjects and compared to fourteen smokers with normal lung function and nine never-smokers.

Results: In smokers with normal lung function, the expression of CD25+CD4was increased, whereas the proportions of FoxP3and CD127were unchanged compared to never-smokers. Among CD4+cells expressing high levels of CD25, the proportion of FoxP3cells was decreased and the percentage of CD127was increased in smokers with normal lung function. CD4+CD25cells with low/absent CD127 expression were increased in smokers with normal lung function, but not in COPD, when compared to never smokers.

Conclusion: The reduction of FoxP3 expression in BALF from smokers with normal lung function indicates that the increase in CD25 expression is not associated with the expansion of regulatory T cells. Instead, the high CD127 and low FoxP3 expressions implicate a predominantly non-regulatory CD25helper T-cell population in smokers and stable COPD. Therefore, we suggest a smoking-induced expansion of predominantly activated airway helper T cells that seem to persist after COPD development.

Place, publisher, year, edition, pages
London: BioMed Central , 2011. Vol. 12, no 74, 8- p.
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:umu:diva-49393DOI: 10.1186/1465-9921-12-74PubMedID: 21651772OAI: oai:DiVA.org:umu-49393DiVA: diva2:455582
Available from: 2011-11-10 Created: 2011-11-10 Last updated: 2017-12-08Bibliographically approved

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