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Molecular wipes: application to epidemic keratoconjuctivitis
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
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2011 (English)In: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 54, no 19, 6670-6675 p.Article in journal (Refereed) Published
Abstract [en]

Epidemic keratoconjunctivitis (EKC) is a severe disease of the eye, caused by members of the Adenoviridae (Ad) family, with symptoms such as keratitis, conjunctivitis, pain, edema, and reduced vision that may last for months or years. There are no vaccines or antiviral drugs available to prevent or treat EKC. It was found previously that EKC-causing Ads use sialic acid as a cellular receptor and demonstrated that soluble, sialic acid-containing molecules can prevent infection. In this study, multivalent sialic acid constructs based on 10,12-pentacosadiynoic acid (PDA) have been synthesized, and these constructs are shown to be efficient inhibitors of Ad binding (IC(50) = 0.9 mu M) and Ad infectivity (IC(50) = 0.7 mu M). The mechanism of action is to aggregate virus particles and thereby prevent them from binding to ocular cells. Such formulations may be used for topical treatment of adenovirus-caused EKC.

Place, publisher, year, edition, pages
Easton, Pa.: American Chemical Society , 2011. Vol. 54, no 19, 6670-6675 p.
Keyword [en]
sialic acid, colorimetric detection, adenovirus type 37, cellular receptor, potent inhibitors, influenza-virus, keratoconjunctivitis, polymerization, infection, liposomes
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:umu:diva-49226DOI: 10.1021/jm200545mISI: 000295546200022OAI: diva2:455771
Available from: 2011-11-11 Created: 2011-11-04 Last updated: 2015-11-14Bibliographically approved

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Marttila, MarkoArnberg, Niklas
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