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Longitudinal structure-function correlates in elderly reveal MTL dysfunction with cognitive decline
Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden . (Univ Oslo, Stockholm Brain Inst, N-0316 Oslo, Norway)
Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden . (Univ Oslo, Stockholm Brain Inst, N-0316 Oslo, Norway)
Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden . (Univ Oslo, Stockholm Brain Inst, N-0316 Oslo, Norway and Univ Oslo, Dept Psychol, N-0316 Oslo, Norway)
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. (Univ Oslo, Stockholm Brain Inst, N-0316 Oslo, Norway)
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2012 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 22, no 10, 2297-2304 p.Article in journal (Refereed) Published
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Abstract [en]

By integrating behavioral measures and imaging data, previous investigations have explored the relationship between biological markers of aging and cognitive functions. Evidence from functional and structural neuroimaging has revealed that hippocampal volume and activation patterns in the medial temporal lobe (MTL) may predict cognitive performance in old age. Most past demonstrations of age-related differences in brain structure-function were based on cross-sectional comparisons. Here, the relationship between 6-year intraindividual change in functional magnetic resonance imaging (fMRI) signal and change in memory performance over 2 decades was examined. Correlations between intraindividual change in fMRI signal during episodic encoding and change in memory performance measured outside of scanning were used as an estimate for relating brain-behavior changes. The results revealed a positive relationship between activation change in the hippocampus (HC) and change in memory performance, reflecting reduced hippocampal activation in participants with declining performance. Using a similar analytic approach as for the functional data, we found that individuals with declining performance had reduced HC volume compared with individuals with intact performance. These observations provide a strong link between cognitive change in older adults and MTL structure and function and thus provide insights into brain correlates of individual variability in aging trajectories.

Place, publisher, year, edition, pages
New York, NY: Oxford University Press , 2012. Vol. 22, no 10, 2297-2304 p.
Keyword [en]
aging, fMRI, hippocampus, longitudinal, memory
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-49410DOI: 10.1093/cercor/bhr306PubMedID: 22065863OAI: oai:DiVA.org:umu-49410DiVA: diva2:455783
Available from: 2011-11-11 Created: 2011-11-11 Last updated: 2017-12-08Bibliographically approved

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Kauppi, KarolinaNyberg, Lars

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