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Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case-control study
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2011 (English)In: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 22, no 11, 1607-1611 p.Article in journal (Refereed) Published
Abstract [en]

Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC). A case-control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case. Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58-1.62) or GCT (OR 1.13, 95% CI 0.51-2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85-1.43) or GCT (OR 0.93, 95% CI 0.68-1.28). Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.

Place, publisher, year, edition, pages
Springer Netherlands, 2011. Vol. 22, no 11, 1607-1611 p.
Keyword [en]
Insulin-like growth factor (IGF-I), C-reactive protein (CRP), Pregnancy, Non-epithelial ovarian cancer, Nested case-control study
National Category
Cancer and Oncology Environmental Health and Occupational Health
URN: urn:nbn:se:umu:diva-49221DOI: 10.1007/s10552-011-9828-2ISI: 000295981400014OAI: diva2:455800
Available from: 2011-11-11 Created: 2011-11-04 Last updated: 2012-08-21Bibliographically approved

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