umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast
Show others and affiliations
2011 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 334, no 6060, 1241-1245 p.Article in journal (Refereed) Published
Abstract [en]

Aβ (beta amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers identified the yeast homolog of phosphatidylinositol binding clathrin assembly protein (PICALM) and other endocytic factors connected to AD whose relationship to Aβ was previously unknown. The factors identified in yeast modified Aβ toxicity in glutamatergic neurons of Caenorhabditis elegans and in primary rat cortical neurons. In yeast, Aβ impaired the endocytic trafficking of a plasma membrane receptor, which was ameliorated by endocytic pathway factors identified in the yeast screen. Thus, links between Aβ, endocytosis, and human AD risk factors can be ascertained using yeast as a model system.

Place, publisher, year, edition, pages
Washington: American association of advancement in science , 2011. Vol. 334, no 6060, 1241-1245 p.
Keyword [en]
genome-wide association, alpha-synuclein, saccharomyces cerevisiae, endoplasmic reticulum, identifies variants, common variants, peptide, oligomers, membrane, cells
National Category
Other Basic Medicine
Identifiers
URN: urn:nbn:se:umu:diva-50077DOI: 10.1126/science.1213210ISI: 000297553600041PubMedID: 22033521OAI: oai:DiVA.org:umu-50077DiVA: diva2:458958
Available from: 2011-11-24 Created: 2011-11-24 Last updated: 2017-12-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Lindhagen-Persson, MalinOlofsson, Anders

Search in DiVA

By author/editor
Lindhagen-Persson, MalinOlofsson, Anders
By organisation
Department of Medical Biochemistry and Biophysics
In the same journal
Science
Other Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 111 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf