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A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix(®) in subjects aged 11-17 years: An open, randomised, controlled trial.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
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2012 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 30, no 4, 774-783 p.Article in journal (Refereed) Published
Abstract [en]

The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix(®)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n=611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both vaccines was shown to be non-inferior to their individual administration. At seven months after the first vaccination, 99.4-100% of the subjects who received both vaccines co-administered showed seroprotection against all meningococcal serogroups and at least 99.1% of them were seropositive for hepatitis A and seroprotected against hepatitis B. This study suggests that MenACWY-TT vaccine could be co-administered with HepA/B without adversely impacting the immunogenicity, safety and reactogenicity of either of the vaccines.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 30, no 4, 774-783 p.
Keyword [en]
Co-administration, Tetravalent meningococcal vaccine, Conjugate vaccine, Twinrix®, Adolescent
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-50200DOI: 10.1016/j.vaccine.2011.11.051PubMedID: 22107850OAI: oai:DiVA.org:umu-50200DiVA: diva2:460118
Available from: 2011-11-29 Created: 2011-11-29 Last updated: 2017-12-08Bibliographically approved

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CiteExportLink to record
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