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Persistence of cell-mediated immunity three decades after vaccination with the live vaccine strain of Francisella tularensis
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för matematik och matematisk statistik. (Computational Life Science Cluster (CLiC))
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
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2011 (Engelska)Ingår i: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 41, nr 4, s. 974-980Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The efficacy of many vaccines against intracellular bacteria depends on the generation of cell-mediated immunity, but studies to determine the duration of immunity are usually confounded by re-exposure. The causative agent of tularemia, Francisella tularensis, is rare in most areas and, therefore, tularemia vaccination is an interesting model for studies of the longevity of vaccine-induced cell-mediated immunity. Here, lymphocyte proliferation and cytokine production in response to F. tularensis were assayed in two groups of 16 individuals, vaccinated 1-3 or 27-34 years previously. As compared to naïve individuals, vaccinees of both groups showed higher proliferative responses and, out of 17 cytokines assayed, higher levels of MIP-1β, IFN-γ, IL-10, and IL-5 in response to recall stimulation. The responses were very similar in the two groups of vaccinees. A statistical model was developed to predict the immune status of the individuals and by use of two parameters, proliferative responses and levels of IFN-γ, 91.1% of the individuals were correctly classified. Using flow cytometry analysis, we demonstrated that during recall stimulation, expression of IFN-γ by CD4(+) CCR7(+) , CD4(+) CD62L(+) , CD8(+) CCR7(+) , and CD8(+) CD62L(+) cells significantly increased in samples from vaccinated donors. In conclusion, cell-mediated immunity was found to persist three decades after tularemia vaccination without evidence of decline.

Ort, förlag, år, upplaga, sidor
Weinheim: Wiley-VCH Verlagsgesellschaft, 2011. Vol. 41, nr 4, s. 974-980
Nyckelord [en]
Cell-mediated immunity, Francisella tularensis, Persistence, Vaccination
Nationell ämneskategori
Immunologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:umu:diva-50333DOI: 10.1002/eji.201040923ISI: 000288821000011PubMedID: 21442618OAI: oai:DiVA.org:umu-50333DiVA, id: diva2:462087
Tillgänglig från: 2011-12-06 Skapad: 2011-12-06 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Eneslätt, KjellRydén, PatrikStöven, SvenjaTärnvik, ArneSjöstedt, Anders

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Institutionen för klinisk mikrobiologiInstitutionen för matematik och matematisk statistik
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