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Development of cardiomyopathy after liver transplantation in Swedish hereditary transthyretin amyloidosis (ATTR) patients
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. (Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. (Ultrasound Department, Beijing Anzhen Hospital, Capital Medical University, Beijing, China)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. (Kardiologi)
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Clinical Physiology.
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2011 (English)In: Amyloid: Journal of Protein Folding Disorders, ISSN 1350-6129, E-ISSN 1744-2818, Vol. 18, no 4, 200-205 p.Article in journal (Refereed) Published
Abstract [en]

Background: Recent studies of liver transplanted (LTx) familial amyloidotic polyneuropathy (FAP) patients have shown a progression of cardiomyopathy in some patients after LTx, but knowledge of the underlying factors remains limited.

Methods: Seventy-five patients, who had undergone LTx from 1996 to 2008, were included. They had all been examined by echocardiography 1-16 months before LTx. Fifty-four had been re-examined 7-34 months, and forty-two 36-137 months after LTx.

Results: A significant increase in interventricular septum (IVS) thickness occurred after LTx (p < 0.01), particularly in males (p = 0.002) and late onset patients (p = 0.003). The development of post-LTx cardiomyopathy was related to patient's age at onset of the disease, male gender and pre-LTx IVS thickness. On multivariate regression analysis, however, age at onset was the only significant predictor for the development of cardiomyopathy (odds ratio = 1.14, 95% confident interval 1.01-1.30, p = 0.04).

Conclusion: An increase of IVS thickness can be observed in FAP patients after LTx. Age at onset of the disease is the main predictor for increased IVS thickness and for the development of cardiomyopathy after liver transplantation.

Place, publisher, year, edition, pages
London: Informa Healthcare, 2011. Vol. 18, no 4, 200-205 p.
Keyword [en]
Amyloidosis-hereditary-neuropathic, cardiomyopathy-hypertrophic, senescence, transplantation-liver, transthyretin
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-50513DOI: 10.3109/13506129.2011.615872ISI: 000296985200005OAI: oai:DiVA.org:umu-50513DiVA: diva2:465009
Available from: 2011-12-14 Created: 2011-12-13 Last updated: 2017-12-08Bibliographically approved

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Okamoto, SadahisaZhao, YingLindqvist, PerBackman, ChristerWijayatunga, PriyanthaHenein, Michael YSuhr, Ole B
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