umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Near infrared and skin impedance spectroscopic in vivo measurements on human skin: development of a diagnostic tool for skin cancer
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery. (Peter Naredi)
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Every year approximately 2800 Swedes are diagnosed with malignant melanoma, the form of cancer that is most rapidly increasing in incidence in the Western world. The earlier we can identify and diagnose a malignant melanoma, the better is the prognosis. In Sweden, 155 000 benign naevi, harmless skin tumours or moles, are surgically excised each year, many of them because melanoma cannot be dismissed by non-invasive methods. The excisions result in substantial medical costs and cause unrest and suffering of the individual patient. For untrained physicians, it is often difficult to make an accurate diagnosis of melanoma, thus a tool that could help to strengthen the diagnosis of suspected melanomas would be highly valuable. This thesis describes the development and assessment of a non-invasive method for early skin cancer detection. Using near infrared (NIR) and skin impedance spectroscopy, healthy and diseased skin of various subjects was examined to develop a new instrument for detecting malignant melanoma. Due to the complex nature of skin and the numerous variables involved, the spectroscopic data were analysed multivariately using Principal Component Analysis (PCA) and partial leas square discriminant analysis (PLS-DA). The reproducibility of the measurements was determined by calculating Scatter Values (SVs), and the significance of separations between overlapping groups in score plots was determined by calculating intra-model distances.

The studies indicate that combining skin impedance and NIR spectroscopy measurements adds value, therefore a new probe-head for simultaneous NIR and skin impedance measurements was introduced. Using both spectroscopic techniques it was possible to separate healthy skin at one body location from healthy skin at another location due to the differences in skin characteristics at various body locations. In addition, statistically significant differences between overlapping groups of both age and gender in score plots were detected. However, the differences in skin characteristics at different body locations had stronger effects on the measurements than both age and gender. Intake of coffee and alcohol prior to measurement did not significantly influence the outcome data. Measurements on dysplastic naevi were significantly separated in a score plot and the influence of diseased skin was stronger than that of body location. This was confirmed in a study where measurements were performed on 12 malignant melanomas, 19 dysplastic naevi and 19 benign naevi. The malignant melanomas were significantly separated from both dysplastic naevi and benign naevi.

Overall, the presented findings show that the instrument we have developed provides fast, reproducible measurements, capable of distinguishing malignant melanoma from dysplastic naevi and benign naevi non-invasively with 83% sensitivity and 95% specificity. Thus, the results are highly promising and the instrument appears to have high potential diagnostic utility.

Place, publisher, year, edition, pages
Umeå: Umeå universitet , 2011. , 51 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1466
Keyword [en]
Combined probe head, Malignant melanoma, diagnosis, NIR, Skin impedance, PCA, PLS-DA
National Category
Surgery
Research subject
Surgery
Identifiers
URN: urn:nbn:se:umu:diva-50605ISBN: 978-91-7459-335-8 (print)OAI: oai:DiVA.org:umu-50605DiVA: diva2:465820
Public defence
2012-01-27, KB3A9, KBC, Umeå universitet, Umeå, 10:00 (English)
Opponent
Supervisors
Available from: 2011-12-23 Created: 2011-12-15 Last updated: 2011-12-23Bibliographically approved
List of papers
1. Characterization of healthy skin using near infrared spectroscopy and skin impedance
Open this publication in new window or tab >>Characterization of healthy skin using near infrared spectroscopy and skin impedance
2008 (English)In: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 46, no 10, 985-995 p.Article in journal (Refereed) Published
Abstract [en]

Near infrared spectroscopy (NIR) and skin impedance (IMP) spectroscopy are two methods suggested for diagnoses of diseases inducing adverse effects in skin. The reproducibility of these methods and their potential value in non-invasive diagnostics were investigated. Measurements were performed in vivo on healthy skin at five anatomic body sites on eight young women. partial least squares discriminant analysis showed that both methods were useful for classification of the skin characteristics at the sites. Inter-individually the NIR model gave 100% correct classification while the IMP model provided 92%. Intra-individually the NIR model gave 88% correct classification whereas the IMP model did not provide any useful classification. The correct classification was increased to 93% when both datasets were combined, which demonstrates the value of adding information. Partial least squares discriminant analysis gave 72% correct predictions of skin sites while the combined model slightly improved to 73%.

Keyword
Near infrared diffuse reflectance spectroscopy, Skin impedance, Multivariate data analysis, Skin characterization, Reproducibility
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:umu:diva-9958 (URN)10.1007/s11517-008-0343-x (DOI)18478287 (PubMedID)
Available from: 2008-11-18 Created: 2008-11-18 Last updated: 2017-12-14Bibliographically approved
2. In vivo skin measurements with a novel probe head for simultaneous skin impedance and near-infrared spectroscopy
Open this publication in new window or tab >>In vivo skin measurements with a novel probe head for simultaneous skin impedance and near-infrared spectroscopy
Show others...
2011 (English)In: Skin research and technology, ISSN 0909-752X, E-ISSN 1600-0846, Vol. 17, no 4, 494-504 p.Article in journal (Refereed) Published
Abstract [en]

Background/purpose: Near-infrared (NIR) spectroscopy and skin impedance (IMP) measurements are useful techniques for objective diagnostics of various skin diseases. Here, we present a combined probe head for simultaneous, time-saving NIR spectroscopy and skin impedance measurements. The probe also ensures that both measurements are performed under equal conditions and at the same skin location.

Methods: Finite element method simulations were performed for evaluation of the impedance. In vivo skin measurements were performed and combined NIR and impedance spectra were analysed by means of multivariate methods with respect to body location, age and gender. The classification rate was determined by a planar discriminant analysis. Reproducibility was investigated by calculation of scatter values and statistical significance between overlapping groups was assessed by the calculation of intra-model distances, q.

Results: The novel probe yielded rapid reproducible results and was easy to manage. Significant differences between skin locations and to a lesser extent age groups and gender were demonstrated.

Conclusion: With the novel probe, statistically significant differences between overlapping classes in score plots can be confirmed by calculating intra-model distances. The influence of molecular differences in the skin at different body locations is larger than the influence of gender or age and therefore relevant reference measurements are discussed.

Place, publisher, year, edition, pages
Wiley, 2011
Keyword
near-infrared spectroscopy, skin impedance, probe development, PCA, PLS-DA, in vivo skin measurement, non-invasive, age, gender, skin characteristics
National Category
Dermatology and Venereal Diseases Biomedical Laboratory Science/Technology
Identifiers
urn:nbn:se:umu:diva-45029 (URN)10.1111/j.1600-0846.2011.00524.x (DOI)21492242 (PubMedID)
Available from: 2011-06-22 Created: 2011-06-20 Last updated: 2017-12-11Bibliographically approved
3. NIR and skin impedance spectroscopic measurements for studying the effect of coffee and alcohol on skin, and dysplastic naevi
Open this publication in new window or tab >>NIR and skin impedance spectroscopic measurements for studying the effect of coffee and alcohol on skin, and dysplastic naevi
Show others...
2012 (English)In: Skin research and technology, ISSN 0909-752X, E-ISSN 1600-0846, Vol. 18, no 4, 486-494 p.Article in journal (Refereed) Published
Abstract [en]

Background/purpose: Near infrared (NIR) and impedance spectroscopy can be used for clinical skin measurements and need to be evaluated for possible confounding factors; (a) are skin conditions of the patient and the subsequent skin measurements influenced by alcohol and/or coffee consumption and (b) are measurements of dysplastic naevi (DN) reproducible over time and significantly different compared to reference skin.

Methods: NIR and skin impedance spectroscopic data were analysed multivariately. In the first study, the skin characteristics of 15 healthy individuals were examined related to body location, gender, individual differences, and consumption of coffee or alcohol. The second study included five patients diagnosed with dysplastic naevi syndrome (DNS). Measurements were taken on DN and reference skin over time.

Results: In the first study, body location and gender had a major influence on measurement scores. Inter-individual skin characteristics and coffee or alcohol effects on skin characteristics were of minor importance. In the second study, it was shown that DN can be differentiated from reference skin and the measurements are stable over time.

Conclusions: Moderate consumption of alcohol and coffee did not influence the results of the measurements. It is possible to follow, stable or changed, characteristics of DN over time.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012
Keyword
Near infrared spectroscopy, skin impedance, multivariate data analysis, atypical naevi/dysplastic naevi syndrome, caffeine, alcohol, skin characteristics
National Category
Surgery
Identifiers
urn:nbn:se:umu:diva-50451 (URN)10.1111/j.1600-0846.2011.00597.x (DOI)
Note

Running Head: Coffee, alcohol and dysplastic naevi Article first published online: 18 DEC 2011

Available from: 2011-12-09 Created: 2011-12-09 Last updated: 2017-12-08Bibliographically approved
4. Non-invasive identification of melanoma with near-infrared and skin impedance spectroscopy
Open this publication in new window or tab >>Non-invasive identification of melanoma with near-infrared and skin impedance spectroscopy
Show others...
2013 (English)In: Skin research and technology, ISSN 0909-752X, E-ISSN 1600-0846, Vol. 19, no 1, e473-e478 p.Article in journal (Refereed) Published
Abstract [en]

Background/purpose: An early diagnosis of cutaneous malignant melanoma is of high importance for good prognosis. An objective, non-invasive instrument could improve the diagnostic accuracy of melanoma and decrease unnecessary biopsies. The aim of this study was to investigate the use of Near infrared and skin impedance spectroscopy in combination as a tool to distinguish between malignant and benign skin tumours.

Methods: Near infrared and skin impedance spectra were collected in vivo on 50 naevi or suspect melanomas prior to excision. Received data was analysed with multivariate techniques and the results were compared to histopathology analyses of the tumours. A total of 12 cutaneous malignant melanomas, 19 dysplastic naevi and 19 benign naevi were included in the study.

Results: The observed sensitivity and specificity of the proposed method were 83% and 95%, respectively, for malignant melanoma.

Conclusions: The results indicate that the combination of near infrared and skin impedance spectroscopy is a promising tool for non-invasive diagnosis of suspect cutaneous malignant melanomas. 

Place, publisher, year, edition, pages
John Wiley & Sons, 2013
Keyword
NIR, PLS-DA classification, combination probe, skin cancer, in vivo
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:umu:diva-50452 (URN)10.1111/j.1600-0846.2012.00668.x (DOI)
Available from: 2011-12-09 Created: 2011-12-09 Last updated: 2017-12-08Bibliographically approved

Open Access in DiVA

Near infrared and skin impedance spectroscopic in vivo measurements on human skin(3409 kB)1652 downloads
File information
File name FULLTEXT01.pdfFile size 3409 kBChecksum SHA-512
cc2e3bf013f4749a4cc4316f5b736e8e6cf6404f59d4c1ca18581173dc1bcaecc3e9f8d5850b1267b089abd4bacf18c20ab95470f6e5fe47ee0c7cc9f10bd711
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Bodén, Ida
By organisation
Surgery
Surgery

Search outside of DiVA

GoogleGoogle Scholar
Total: 1652 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
Total: 1498 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf