Shorter telomere length is linked to brain atrophy and white matter hyperintensities
2014 (English)In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 43, no 2, 212-217 p.Article in journal (Refereed) Published
Background: leukocyte telomere length (TL) is considered a marker of biological aging. Several studies have investigated the link between leukocyte TL and aging-associated functional attributes of the brain, but no prior study has investigated whether TL can be linked to brain atrophy and white matter hyperintensities (WMHs); two prominent structural manifestations of brain aging. Methods: we investigated whether leukocyte TL was related to brain atrophy and WMHs in a sample of 102 non-demented individuals aged 64-75 years. Results: shorter TL was related to greater degree of subcortical atrophy (beta = -0.217, P = 0.034), but not to cortical atrophy. Furthermore, TL was 371 bp shorter (P = 0.041) in participants exhibiting subcortical WMHs, and 552 bp shorter (P = 0.009) in older participants exhibiting periventricular WMHs. Conclusion: this study provides the first evidence of leukocyte TL being associated with cerebral subcortical atrophy and WMHs, lending further support to the concept of TL as a marker of biological aging, and in particular that of the aging brain.
Place, publisher, year, edition, pages
2014. Vol. 43, no 2, 212-217 p.
brain atrophy, older people, telomere length, white matter hyperintensities
IdentifiersURN: urn:nbn:se:umu:diva-50629DOI: 10.1093/ageing/aft172ISI: 000332028600012PubMedID: 24231584OAI: oai:DiVA.org:umu-50629DiVA: diva2:466451
Originally published in manuscript form with title The relationship of leukocyte telomere length with brain atrophy and white matter hyperintensities. 2011-12-162011-12-162016-06-02Bibliographically approved