Identification of regulatory regions within the intron sequence of the toy gene
(English)Manuscript (preprint) (Other academic)
In Drosophila there are two paralougus Pax-6 genes, twin of eyeless (toy) and eyeless (ey) Both genes have an extensive elaborate expression pattern in the brain and ventral nerve cord but are not activated at the same time in these regions. Since both genes are expressed in several tissues during different time points in development, one might expect that more than one regulatory enhancer controls them. It is known, that eyeless is directly regulated by toy at the beginning of eye development and it has been shown that there are binding sites for regulatory proteins within the introns of the eyeless gene and in vertebrate Pax-6 genes. We investigate the transcriptional activation of toy within the intron sequences of the gene and show that there is a presumptive regulatory element in intron 2, controlling toy expression in the ventral nerve cord of embryos.
Research subject Molecular Biology
IdentifiersURN: urn:nbn:se:umu:diva-50723OAI: oai:DiVA.org:umu-50723DiVA: diva2:467811