Change search
ReferencesLink to record
Permanent link

Direct link
Intense CD44 expression is a negative prognostic factor in tonsillar and base of tongue cancer
Center for Clinical Research Dalarna, Falun, Sweden .
Show others and affiliations
2012 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 32, no 1, 153-161 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Patients with tonsillar and base of tongue cancer, which are human papillomavirus (HPV) positive, have a better clinical outcome than those with HPV-negative tumors. The identification of additional predictive markers for response to therapy could still be of great use.

MATERIALS AND METHODS: Tumor markers CD44, p16, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), E-cadherin, cyclooxygenase-2 (COX 2), Ki-67, and p27 were analyzed by immunochemistry, and HPV status was tested by polymerase chain reaction (PCR) in tumors from 73 patients and correlated to survival.

RESULTS: High intensity CD44 staining (p=0.006) and high EGFR expression (p=0.026) were indicators of poor prognosis, while high p16 expression (p=0.021) and younger age (p=0.002) were positive prognostic markers for disease-specific survival. Furthermore, staining of CD44 (p=0.026) and age (p=0.002) were shown to be strong prognostic markers in multivariate analysis, which should be evaluated further for possible use in clinical practice.

Place, publisher, year, edition, pages
2012. Vol. 32, no 1, 153-161 p.
Keyword [en]
Tonsillar cancer, CD44, p16, EGFR, VEGF, p27
National Category
Cancer and Oncology
Research subject
URN: urn:nbn:se:umu:diva-51002PubMedID: 22213301OAI: diva2:473279
Swedish Research Council
Available from: 2012-01-05 Created: 2012-01-05 Last updated: 2012-03-29Bibliographically approved

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Lindquist, David
In the same journal
Anticancer Research
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 50 hits
ReferencesLink to record
Permanent link

Direct link