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Brain activation patterns in major depressive disorder and work stress-related long-term sick leave among swedish females
Remonthagen Stroke och hjärnskadecenter, Östersund.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
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2012 (English)In: Stress, ISSN 1025-3890, Vol. 15, no 5, 503-513 p.Article in journal (Refereed) Published
Abstract [en]

Deficits in executive and working-memory functioning associated with frontal lobe dysfunction are prominent in depression and work-related long-term sick leave (LTSL). This study used functional magnetic resonance imaging (fMRI) to investigate potential differences in brain activation patterns in these conditions. In addition, the function of the hypothalamic-pituitary-adrenal (HPA)-axis was examined and compared between groups. Since there is a clear overrepresentation of women in these diagnostic groups, and to ensure a more homogenous sample population, only women were included. To examine the neural correlates of relevant cognitive processes in patients on sick-leave > 90 days due to work-related LTSL, recently diagnosed patients with major depression (DSM-IV criteria, untreated), and healthy controls (n=10 each group), a 2-back working memory task and a visual long-term memory task were administered during fMRI scanning. HPA-axis functioning was investigated using a diurnal curve of saliva cortisol and a dexamethasone suppression test. Task performance was comparable among the three groups. Multivariate image analysis revealed that both memory tasks engaged a similar brain network in all three groups, including the prefrontal and parietal cortex. During the 2-back task, LTSL patients had significant frontal hypoactivation compared to controls and patients with depression. Saliva cortisol measurements showed a flattening of the diurnal rythmicity in LTSL patients compared to patients with depression and healthy contols. Taken together, these findings indicate that work stress-related LTSL and major depression are dissociable in terms of frontal activation and diurnal cortisol rhythmicity.

Place, publisher, year, edition, pages
London: Informa Healthcare, 2012. Vol. 15, no 5, 503-513 p.
Keyword [en]
blood pressure, cohort study, epidemiology, high-grade glioma, meningioma, metabolic syndrome, primary brain tumour, risk factors
National Category
Environmental Health and Occupational Health Endocrinology and Diabetes
URN: urn:nbn:se:umu:diva-51068DOI: 10.3109/10253890.2011.646347ISI: 000307904200006PubMedID: 22217254OAI: diva2:474847
Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2013-10-28Bibliographically approved

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