Brain activation patterns in major depressive disorder and work stress-related long-term sick leave among swedish females
2012 (English)In: Stress, ISSN 1025-3890, Vol. 15, no 5, 503-513 p.Article in journal (Refereed) Published
Deficits in executive and working-memory functioning associated with frontal lobe dysfunction are prominent in depression and work-related long-term sick leave (LTSL). This study used functional magnetic resonance imaging (fMRI) to investigate potential differences in brain activation patterns in these conditions. In addition, the function of the hypothalamic-pituitary-adrenal (HPA)-axis was examined and compared between groups. Since there is a clear overrepresentation of women in these diagnostic groups, and to ensure a more homogenous sample population, only women were included. To examine the neural correlates of relevant cognitive processes in patients on sick-leave > 90 days due to work-related LTSL, recently diagnosed patients with major depression (DSM-IV criteria, untreated), and healthy controls (n=10 each group), a 2-back working memory task and a visual long-term memory task were administered during fMRI scanning. HPA-axis functioning was investigated using a diurnal curve of saliva cortisol and a dexamethasone suppression test. Task performance was comparable among the three groups. Multivariate image analysis revealed that both memory tasks engaged a similar brain network in all three groups, including the prefrontal and parietal cortex. During the 2-back task, LTSL patients had significant frontal hypoactivation compared to controls and patients with depression. Saliva cortisol measurements showed a flattening of the diurnal rythmicity in LTSL patients compared to patients with depression and healthy contols. Taken together, these findings indicate that work stress-related LTSL and major depression are dissociable in terms of frontal activation and diurnal cortisol rhythmicity.
Place, publisher, year, edition, pages
London: Informa Healthcare, 2012. Vol. 15, no 5, 503-513 p.
blood pressure, cohort study, epidemiology, high-grade glioma, meningioma, metabolic syndrome, primary brain tumour, risk factors
Environmental Health and Occupational Health Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:umu:diva-51068DOI: 10.3109/10253890.2011.646347ISI: 000307904200006PubMedID: 22217254OAI: oai:DiVA.org:umu-51068DiVA: diva2:474847