Change search
ReferencesLink to record
Permanent link

Direct link
Factors associated with inflammation markers, a cross-sectional analysis
Show others and affiliations
2011 (English)In: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 56, no 3, 769-778 p.Article in journal (Refereed) Published
Abstract [en]

Epidemiological studies have reported associations between circulating inflammation markers and risk of chronic diseases. It is of interest to examine whether risk factors for these diseases are associated with inflammation. We conducted a cross-sectional analysis to evaluate whether reproductive and lifestyle factors and circulating vitamin D were associated with inflammation markers, including C-reactive protein, cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, TNFα), and cytokine modulators (IL-1RA, sIL-1RII, sIL-2Ra, sIL-4R, sIL-6R, sTNF-R1/R2), among 616 healthy women. We confirmed associations of several inflammation markers with age and BMI. We also observed significantly higher levels of certain inflammation markers in postmenopausal vs. premenopausal women (TNFα, sIL-1RII, sIL-2Ra), with increasing parity (IL-12p40), and with higher circulating 25(OH) vitamin D (IL-13) and lower levels among current users of non-steroidal anti-inflammatory drugs (NSAIDs) (IL-1β, IL-2, IL-10, IL-12p70, and IL-12p40), current smokers (IL-4, IL-13, IL-12p40), and women with a family history of breast or ovarian cancer (IL-4, IL-10, IL-13). Our findings suggest that risk factors for chronic diseases (age, BMI, menopausal status, parity, NSAID use, family history of breast and ovarian cancer, and smoking) are associated with inflammation markers in healthy women.

Place, publisher, year, edition, pages
2011. Vol. 56, no 3, 769-778 p.
Keyword [en]
C-reactive protein; Cross-sectional studies; Cytokines; Cytokine receptors; Epidemiologic factors
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Cell and Molecular Biology Immunology in the medical area
URN: urn:nbn:se:umu:diva-51188DOI: 10.1016/j.cyto.2011.09.013PubMedID: 22015105OAI: diva2:476774
Available from: 2012-01-12 Created: 2012-01-12 Last updated: 2015-04-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hallmans, GöranIdahl, AnnikaLundin, EvaOhlson, Nina
By organisation
Nutritional ResearchObstetrics and GynaecologyPathology
In the same journal
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Cell and Molecular BiologyImmunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 54 hits
ReferencesLink to record
Permanent link

Direct link