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Comparing health outcomes and costs of general vaccination with pneumococcal conjugate vaccines in sweden: a markov model.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
2012 (English)In: Clinical Therapeutics, ISSN 0149-2918, E-ISSN 1879-114X, Vol. 34, no 1, 177-89 p.Article in journal (Refereed) Published
Abstract [en]

Background: Two new pneumococcal conjugate vaccines were licensed to immunize infants and young children against pneumococcal disease.

Objectives: The objective of this study was to estimate the expected health benefits, costs, and incremental cost-effectiveness of routine vaccination with the 10-valent pneumococcal nontypeable hemophilus influenza protein-D conjugate vaccine (PHiD-CV) compared with the 13-valent pneumococcal conjugate vaccine (PCV13) in Sweden.

Methods: A Markov cohort model was used to estimate the effect of vaccination at vaccine steady state, taking a societal perspective and using a 2+1 vaccination schedule. Price parity was assumed between the vaccines. Outcomes were measured by reduction in disease burden, costs, quality-adjusted life–years (QALYs) and incremental cost-effectiveness ratio.

Results: The results predicted that PCV13 would prevent 3 additional cases of invasive pneumococcal disease and 34 additional cases of pneumonia, whereas PHiD-CV would avoid 3 additional cases of mastoiditis, 1010 tube insertions, and 10,420 cases of ambulatory acute otitis media compared with PCV13. By combining morbidity and mortality benefits of all clinical outcomes, PHiD-CV would generate 45.3 additional QALYs compared with PCV13 and generate savings of an estimated 62 million Swedish kronors.

Conclusion: The present study predicted lower costs and better health outcome (QALYs) gained by introducing PHiD-CV compared with PCV13 in routine vaccination. Our results indicated that PHiD-CV is cost-effective compared with PCV13 in Sweden.

Place, publisher, year, edition, pages
2012. Vol. 34, no 1, 177-89 p.
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
URN: urn:nbn:se:umu:diva-51832DOI: 10.1016/j.clinthera.2011.12.007ISI: 000300337300015PubMedID: 22284997OAI: diva2:489493
Available from: 2012-02-03 Created: 2012-02-03 Last updated: 2012-03-23Bibliographically approved

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