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Adaptive and innate immune responsiveness to Borrelia burgdorferi sensu lato in exposed Asymptomatic children and children with Previous Clinical Lyme Borreliosis
Department of Pediatrics, Falun General Hospital, Falun, Sweden. (Centre for Clinical Research in Dalarna, Falun, Sweden)
Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
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2012 (English)In: Clinical & Developmental Immunology, ISSN 1740-2522, E-ISSN 1740-2530, Vol. 2012, 294587-294597 p.Article in journal (Refereed) Published
Abstract [en]

Why some individuals develop clinical manifestations in Lyme borreliosis (LB) while others remain asymptomatic is largely unknown. Therefore, we wanted to investigate adaptive and innate immune responsiveness to Borrelia burgdorferi sensu lato in exposed Borrelia-antibody-positive asymptomatic children (n = 20), children with previous clinical LB (n = 24), and controls (n = 20). Blood samples were analyzed for Borrelia-specific interferon (IFN)-gamma, interleukin (IL)-4, and IL-17 secretion by ELISPOT and Borrelia-induced IL-1 beta, IL-6, IL-10, IL-12(p70), and tumor necrosis factor (TNF) secretion by Luminex. We found no significant differences in cytokine secretion between groups, but a tendency towards an increased spontaneous secretion of IL-6 was found among children with previous clinical LB. In conclusion, the adaptive or innate immune responsiveness to Borrelia burgdorferi sensu lato was similar in Borrelia-exposed asymptomatic children and children with previous clinical LB. Thus, the immunological mechanisms of importance for eradicating the spirochete effectively without developing clinical manifestations of LB remain unknown.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2012. Vol. 2012, 294587-294597 p.
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Immunology in the medical area
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URN: urn:nbn:se:umu:diva-52036DOI: 10.1155/2012/294587ISI: 000298814000001OAI: oai:DiVA.org:umu-52036DiVA: diva2:493187
Available from: 2012-02-08 Created: 2012-02-08 Last updated: 2017-12-07Bibliographically approved

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Bergström, Sven

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