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Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS
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2012 (English)In: Amyotrophic Lateral Sclerosis and other Motor Neuron Disorders, ISSN 1466-0822, E-ISSN 1743-4483, Vol. 13, no 1, 1-10 p.Article, review/survey (Refereed) Published
Abstract [en]

Despite major advances in deciphering the neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), validated neurochemical biomarkers for monitoring disease activity, earlier diagnosis, defining prognosis and unlocking key pathophysiological pathways are lacking. Although several candidate biomarkers exist, translation into clinical application is hindered by small sample numbers, especially longitudinal, for independent verification. This review considers the potential routes to the discovery of neurochemical markers in ALS, and provides a consensus statement on standard operating procedures that will facilitate multicenter collaboration, validation and ultimately clinical translation.

Place, publisher, year, edition, pages
2012. Vol. 13, no 1, 1-10 p.
Keyword [en]
Biomarker, biobank, proteomics, cerebrospinal fluid, brain bank
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-52033DOI: 10.3109/17482968.2011.627589ISI: 000298746800001OAI: oai:DiVA.org:umu-52033DiVA: diva2:494191
Available from: 2012-02-08 Created: 2012-02-08 Last updated: 2017-12-07Bibliographically approved

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Wuolikainen, Anna
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Department of Chemistry
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