Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study.
2012 (English)In: Haematologica, ISSN 0390-6078, E-ISSN 1592-8721, Vol. 97, no 6, 854-858 p.Article in journal (Refereed) Published
No comprehensive evaluation has been conducted to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population-based data from Sweden, we estimated risk of infections among 5,326 MGUS patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P<0.05) of developing any infection at 5 and 10 years of follow-up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P<0.05) of bacterial infections (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and viral infections (influenza and herpes zoster). Patients with monoclonal gammopathy of undetermined significance with M-protein concentrations >2.5 g/dL at diagnosis had highest risks of infections; however, the risk was also increased (P<0.05) among those with concentrations <0.5 g/dL. Patients with monoclonal gammopathy of undetermined significance who developed infections had no excess risk of developing multiple myeloma. Our findings provide novel clues for the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications.
Place, publisher, year, edition, pages
Ferrata Storti Foundation, 2012. Vol. 97, no 6, 854-858 p.
MGUS, infections, multiple myeloma, bacteria, virus
IdentifiersURN: urn:nbn:se:umu:diva-52293DOI: 10.3324/haematol.2011.054015ISI: 000306066500014PubMedID: 22180421OAI: oai:DiVA.org:umu-52293DiVA: diva2:503679