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Promiscuous DNA synthesis by human DNA polymerase θ
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
2012 (English)In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 40, no 6, 2611-2622 p.Article in journal (Refereed) Published
Abstract [en]

The biological role of human DNA polymerase θ (POLQ) is not yet clearly defined, but it has been proposed to participate in several cellular processes based on its translesion synthesis capabilities. POLQ is a low-fidelity polymerase capable of efficient bypass of blocking lesions such as abasic sites and thymine glycols as well as extension of mismatched primer termini. Here, we show that POLQ possesses a DNA polymerase activity that appears to be template independent and allows efficient extension of single-stranded DNA as well as duplex DNA with either protruding or multiply mismatched 3'-OH termini. We hypothesize that this DNA synthesis activity is related to the proposed role for POLQ in the repair or tolerance of double-strand breaks.

Place, publisher, year, edition, pages
2012. Vol. 40, no 6, 2611-2622 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-52307DOI: 10.1093/nar/gkr1102ISI: 000302312400028PubMedID: 22135286OAI: oai:DiVA.org:umu-52307DiVA: diva2:503899
Available from: 2012-02-17 Created: 2012-02-17 Last updated: 2017-12-07Bibliographically approved

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Hogg, MatthewSauer-Eriksson, A ElisabethJohansson, Erik
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Department of Medical Biochemistry and BiophysicsDepartment of Chemistry
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Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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