Change search
ReferencesLink to record
Permanent link

Direct link
Epstein-Barr virus and multiple sclerosis: interaction with HLA
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Show others and affiliations
2012 (English)In: Genes and Immunity, ISSN 1466-4879, E-ISSN 1476-5470, Vol. 13, no 1, 14-20 p.Article in journal (Refereed) Published
Abstract [en]

Epstein-Barr virus (EBV) infection, history of infectious mononucleosis (IM) and HLA-A and DRB1 have all been proposed as risk factors for multiple sclerosis (MS). Our aim was to analyse possible interactions between antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA1) or EBNA1 fragments, presence of DRB1*15 and absence of A*02. The study population includes newly diagnosed cases and matched controls. Interaction on the additive scale was calculated using attributable proportion due to interaction (AP), which is the proportion of the incidence among individuals exposed to two interacting factors that is attributable to the interaction per se. IM showed association with MS, odds ratio (OR) = 1.89 (1.45-2.48% confidence interval (Cl)), as did raised EBNA1 IgG OR = 1.74 (1.38-2.18 95%CI). All EBNA1 fragment IgGs were associated with MS risk. However, EBNA1 fragment 385-420 IgG levels were more strongly associated to MS than total EBNA1 IgG, OR = 3.60 (2.75-4.72 95%CI), and also interacted with both DRB1*15 and absence of A*02, AP 0.60 (0.45-0.76 95%CI) and AP 0.39 (0.18-0.61 95%CI), respectively. The observed interaction between HLA class I and 11 genotype and reactivity to EBV-related epitopes suggest that the mechanism through which HLA genes influence the risk of MS may, at least in part, involve the immune control of EBV infection.

Place, publisher, year, edition, pages
2012. Vol. 13, no 1, 14-20 p.
Keyword [en]
multiple sclerosis, Epstein-Barr virus, HLA, interactions, case–control study
National Category
URN: urn:nbn:se:umu:diva-52392DOI: 10.1038/gene.2011.42ISI: 000299596900002OAI: diva2:504349
Available from: 2012-02-20 Created: 2012-02-20 Last updated: 2012-04-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sundström, Peter
By organisation
Clinical Neuroscience
In the same journal
Genes and Immunity

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 39 hits
ReferencesLink to record
Permanent link

Direct link