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Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me-Can)
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2012 (English)In: Gynecologic Oncology, ISSN 0090-8258, E-ISSN 1095-6859, Vol. 125, no 2, 330-335 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Little is known about the association between metabolic risk factors and cervical cancer carcinogenesis.

MATERIAL AND METHODS: During mean follow-up of 11years of the Me-Can cohort (N=288,834) 425 invasive cervical cancer cases were diagnosed. Hazard ratios (HRs) were estimated by the use of Cox proportional hazards regression models for quintiles and standardized z-scores (with a mean of 0 and a SD of 1) of BMI, blood pressure, glucose, cholesterol, triglycerides and MetS score. Risk estimates were corrected for random error in the measurements.

RESULTS: BMI (per 1SD increment) was associated with 12%, increase of cervical cancer risk, blood pressure with 25% and triglycerides with 39%, respectively. In models including all metabolic factors, the associations for blood pressure and triglycerides persisted. The metabolic syndrome (MetS) score was associated with 26% increased corrected risk of cervical cancer. Triglycerides were stronger associated with squamous cell carcinoma (HR 1.48; 95% CI, 1.20-1.83) than with adenocarcinoma (0.92, 0.54-1.56). Among older women cholesterol (50-70years 1.34; 1.00-1.81), triglycerides (50-70years 1.49, 1.03-2.16 and ≥70years 1.54, 1.09-2.19) and glucose (≥70years 1.87, 1.13-3.11) were associated with increased cervical cancer risk.

CONCLUSION: The presence of obesity, elevated blood pressure and triglycerides were associated with increased risk of cervical cancer.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 125, no 2, 330-335 p.
Keyword [en]
Metabolic factors, Cervical cancer, Epidemiology, CONOR
National Category
Cancer and Oncology
URN: urn:nbn:se:umu:diva-52448DOI: 10.1016/j.ygyno.2012.01.052ISI: 000303227500011PubMedID: 22330614OAI: diva2:504675
Available from: 2012-02-21 Created: 2012-02-21 Last updated: 2015-04-22Bibliographically approved

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