Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning for chronic lymphocytic leukemia in Sweden: Does donor T-cell engraftment 3 months after transplantation predict survival?
2012 (English)In: Leukemia and Lymphoma, ISSN 1042-8194, Vol. 53, no 9, 1699-1705 p.Article in journal (Refereed) Published
Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute GVHD grades II-IV and chronic GVHD were 29% and 48%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall survival (OS) were 18%, 47% and 74% at 1 year, and 21%, 25% and 45% at 5 years, respectively. T-cell chimerism after transplantation was measured in 31 out of 34 patients (91%) surviving beyond day +100. Seventeen patients achieved >90% donor T-cell engraftment at 3 months after allo-SCT and, compared with the 12 patients with ≤90% donor T-cell engraftment, they showed favorable PFS at 1 year (82% vs. 33%, P=0.002), and better long-term PFS and OS (P=0.002 and 0.05 respectively). Donor T-cell engraftment of >90% at 3 months after RIC allo-SCT for CLL seems to predict favorable short-term and long-term outcome.
Place, publisher, year, edition, pages
London: Informa Healthcare, 2012. Vol. 53, no 9, 1699-1705 p.
Allogeneic stem cell transplantation, Chronic lymphocytic leukemia, Tcell, Donor engraftment
Cancer and Oncology
IdentifiersURN: urn:nbn:se:umu:diva-52609DOI: 10.3109/10428194.2012.666661ISI: 000307301500012PubMedID: 22335529OAI: oai:DiVA.org:umu-52609DiVA: diva2:506060