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Ways and means of eukaryotic mRNA decay
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2012 (English)In: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, ISSN 1874-9399, Vol. 1819, no 6, 593-603 p.Article, review/survey (Refereed) Published
Abstract [en]

Messenger RNA degradation is an important point of control for gene expression. Genome-wide studies on mRNA stability have demonstrated its importance in adaptation and stress response. Most of the key players in mRNA decay appear to have been identified. The study of these proteins brings insight into the mechanism of general and specific targeting of transcripts for degradation. Recruitment and assembly of mRNP complexes enhance and bring specificity to mRNA decay. mRNP complexes can form larger structures that have been found to be ubiquitous in nature. Discovery of P-Bodies, an archetype of this sort of aggregates, has generated interest in the question of where mRNA degrades. This is currently an open question under extensive investigation. This review will discuss in detail the recent developments in the regulation of mRNA decay focusing on yeast as a model system. 

Place, publisher, year, edition, pages
New York: Elsevier, 2012. Vol. 1819, no 6, 593-603 p.
Keyword [en]
mRNA decay, P-bodies, mRNA turnover, Decapping
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-52614DOI: 10.1016/j.bbagrm.2012.01.001ISI: 000304219400014OAI: oai:DiVA.org:umu-52614DiVA: diva2:506135
Funder
Swedish Research Council, 621-2010-4602
Available from: 2012-03-01 Created: 2012-02-27 Last updated: 2012-07-03Bibliographically approved

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Nissan, Tracy

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